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Science & Research

Science Supporting Metabolic-Based Therapies

Ketogenic Diet and Metabolic Therapies (Book) 

Cancer as a Metabolic Disease (Article; FREE)

Cancer as a Metabolic Disease (Book)

 

Hyperbaric Oxygen Research

Ketogenic Diet and Hyperbaric Oxygen Prolong Survival in Mice with Metastatic Cancer

Press Report: KD and Hyperbaric Oxygen for Cancer

Hyperbaric Oxygen for Traumatic Brain Injury

Combination Ketogenic Diet, Ketone Supplementation and Hyperbaric Oxygen Therapy for Cancer

Effect of hyperbaric oxygen with radiation therapy for malignant gliomas

 

Cancer Research and Review Articles (FREE Access)

Cancer as a Metabolic Disease: Implications for Novel Therapeutics(Carcinogenesis 2013) 

Cancer as a Metabolic Disease (Seyfried and Sheldon, 2010) 

Insulin Inhibition as Metabolic Therapy for Cancer (Eugene Fine et al. 2012) 

Ketone Supplementation Prolongs Survival from Metastatic Cancer Ketogenic Diet and Radiation for Brain Tumors (Abdelwahab et al. 2012) 

Metabolic Management of Brain Cancer  (Zuccoli et al. 2010) 

Metabolic Syndrome and Cancer (Review) (Champ et al, 2012) 

Ketogenic Diet and Related Dietary Treatments Ketogenic Diet Preserves Muscle  

Ketones and Brain Metabolism  

Fasting and Brain Metabolism 

Ketone Bodies: Potential Therapeutic Uses (Richard Veech) 

What Causes Cancer? 

What is the Origin of Cancer? (Robb Wolf's blog) 

Hyperbaric Oxygen for Cancer Metabolic Reprogramming

Ketone Bodies in Pancreatic Cancer New York Times Article (Unpublished information)   

 

ALS Studies

Deanna Protocol as a Metabolic Therapy for ALS 

MCT oil and ALS pathology  

Neuroprotection with Metabolic Therapy 

Ketogenic Diet as a Metabolic Therapy for ALS 

 

 

Research Papers, free downloads

Dominic`s Publication list:

1.     Ari C., Koutnik AP., DeBlasi J., Landon C., Rogers CQ., Vallas J., Bharwani S., Puchowicz M., Bederman I., Diamond DM., Kindy MS., Dean JB., D’Agostino DP. Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements. Physiological Reports. 2019 Jan;7(1):e13961.

2.     Ari C, Kovács Z, Murdun C, Koutnik AP, Goldhagen CR, Rogers CQ, Diamond D,  D’Agostino DP. Nutritional ketosis delays the onset of isoflurane induced anesthesia BMC Anesthesiology; 2018; 18:85; https://doi.org/10.1186/s12871-018-0554-0

3.     Stubbs BJ, Koutnik AP, Poff AM, Ford KM, D'Agostino DP. Commentary: Ketone Diester Ingestion Impairs Time-Trial Performance in Professional Cyclists. Frontiers Physiol. 2018 Mar 27;9:279. doi: 10.3389/fphys.2018.00279.

4.     Kovacs Z, D'Agostino DP, Ari C. Anxiolytic effect of exogenous ketone supplementation was abolished by adenosine A1 receptor inhibition in Wistar Albino Glaxo/Rijswijk rats. Front. Behav. Neurosci., 22 February 2018;  https://doi.org/10.3389/fnbeh.2018.00029  

5.      Poff AM, Koutnik AP, Egan KM, Sahebjum S, D’Agostino DP, Kumar NB. Targeting the Warburg Effect: Implications for Management of Glioma. Seminars in Cancer Biology. Seminars in Cancer Biol. 2017 Dec 30. pii: S1044-579X(17)30124-4. doi:10.1016/j.semcancer.2017.12.011.

6.     Kephart WC, Mumford PW, Mao X, Romero MA, Hyatt HW, Zhang Y, Mobley CB,Quindry JC, Young KC, Beck DT, Martin JS, McCullough DJ, D'Agostino DP, Lowery RP, Wilson JM, Kavazis AN, Roberts MD. The 1-Week and 8-Month Effects of a Ketogenic Diet or Ketone Salt Supplementation on Multi-Organ Markers of Oxidative Stress and Mitochondrial Function in Rats. Nutrients. 2017 Sep 15;9(9). pii:E1019. doi: 10.3390/nu9091019. PubMed PMID: 28914762

7.     Kovacs Z, D'Agostino DP, Dobolyi A, Ari C. Adenosine A1 receptor antagonism abolished the anti-seizure effects of exogenous ketone supplementation in Wistar Albino Glaxo Rijswijk rats. June 2017 Front. Mol. Neurosci. doi: 10.3389/fnmol.2017.00235

8.     Ward NP, Poff AM, Koutnik AP, D'Agostino DP. Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells. PLoS One. 2017 Jun 23;12(6):e0180061. doi:10.1371/journal.pone.0180061. eCollection 2017. PubMed PMID: 28644886.

9.     Klement R, Feinman RD, Gross EC, Champ CE, D’Agostino DP, Fine EJ, Kammerer U, Poff A, Rho JM, Seyfried TN, Scheck AC. (2017) Need for revised review of article on ketogenic dietary regimes for cancer, Medical Oncology. (2017) 34:108; DOI 10.1007/s12032-017-0968-4 

10.  Wilson JM, Lowery RP, Roberts MD, Sharp MH, Joy JM, Shields KA, Partl J, Volek JS, D'Agostino DP. The Effects of Ketogenic Dieting on Body Composition, Strength, Power, and Hormonal Profiles in Resistance Training Males. J Strength Cond Res. 2017 Apr 7. doi: 10.1519/JSC. 001935. PubMed PMID: 28399015.

11.  Somlyai G, Collins QT, Meuillet EJ, Hitendra P, D’Agostino DP, Boros LG. (2017) Structural homologies between Phenformin, Lipitor and Gleevec aim the same metabolic oncotarget in leukemia and melanoma. Oncotarget. Mar 15. doi: 10.18632/oncotarget.16238

12.  Seyfried TN, Yu G, Maroon JC, D'Agostino DP. Press-pulse: a novel therapeutic strategy for the metabolic management of cancer. Nutr Metab (Lond). 2017 Feb 23;14:19. doi: 10.1186/s12986-017-0178-2. eCollection 2017. PubMed PMID:28250801; PubMed Central PMCID: PMC5324220.

13.  Ari C. Canfield CE; Copes N, Poff AM, Fiorelli TN, Landon CS, Goldhagen CR, Mavromates N, D’Agostino DP. (2017) Biochemical alterations in Amyotrophic Lateral Sclerosis (ALS) Mouse Model resulted from the Deanna Protocol Supplement Complex. Metabolomics 13:55; DOI 10.1007/s11306-017-1183-1

14.  Ari C, Kovacs Z, Juhasz G, Murdun C, Goldhagen CR, Koutnik A, Poff AM, Kesl SL,  D’Agostino DP. (2016) Exogenous ketone supplements reduce anxiety-related behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk rats. Frontiers Molecular Neuroscience; 9: 137. doi:  10.3389/fnmol.2016.00137

15.  Poff, A. M., Kernagis, D. and D'Agostino, DP. 2016. Hyperbaric Environment: Oxygen and Cellular Damage versus Protection. Comprehensive Physiology. 7:213–234.

16.  Egan B, D'Agostino DP. (2016) Fueling Performance: Ketones Enter the Mix. Cell Metabolism. Sep 13;24(3):373-5. doi: 10.1016/j.cmet.2016.08.021

17.  Ciarlone SL; Grieco JC, D'Agostino DP, Weeber E. Ketone ester supplementation attenuates seizure activity, and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model. Neurobiology of Disease (2016)  Dec;96:38-46.  doi: 10.1016/j.nbd.2016.08.002.

18.  Colquhoun RJ, Gai1 CM, Walters J, Brannon A, Kilpatrick MW, D’Agostino DP; Campbell BI. Comparison of Powerlifting Performance in Trained Males Using Traditional and Flexible Daily Undulating Periodization. J Strength Cond Res. 2017 Feb;31(2):283-291. DOI: 10.1519/JSC.01500

19.  Kesl SL, Poff AM, Ward NP, Fiorelli TN, Ari C, Van Putten AJ, Sherwood JW, Arnold P, D’Agostino DP. (2015) Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats. Nutrition and Metabolism; 2016 Feb 4;13:9. doi: 10.1186/s12986-016-0069-y

20.  Ari C, D’Agostino DP. Contingency checking and self-directed behaviors in giant manta rays: do fish have self-awareness? Journal of Ethology, May 2016, Volume 34, Issue 2, pp 167-174.

21.  Viggiano A, Pilla R, Arnold P, Marcellino M, D’Agostino DP, Zeppa P, Coppola G. Different calorie restriction treatments have similar anti-seizure efficacy. Seizure-European Journal of Epilepsy; 2016 Feb;35:45-9. doi: 10.1016/j.seizure.2016.01.003

22.  Boros L, D’Agostino DP, Katz HE, Roth JP, Meuillet EJ, Somlyati G. Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. Medical Hypotheses 87 (2016) 69–74; DOI: http://dx.doi.org/10.1016/j.mehy.2015.11.016

23.  Poff A, Ward N, Seyfried T, Arnold P, D’Agostino DP. A novel non-toxic metabolic therapy – ketogenic diet, ketone supplementation, and hyperbaric oxygen – elicit potent anti-cancer effects in vitro and in vivo. PloS One. 2015 Jun 10;10(6):e0127407. DOI: 10.1371/journal.pone.0127407

24.  Viggiano A, Pilla R, Arnold P, Marcellino M, D’Agostino DP, Coppola G. (2015) Anticonvulsant properties of an oral ketone ester in a pentylenetetrazole-model of seizure. Brain Res. 2015 May 27. pii: S0006-8993(15)00425-4. DOI: 10.1016/j.brainres.2015.05.023.

25.  Youm Y, Nguyen K, Grant RW, Golgberg EL, Bodogai M, Kim D, D’Agostino DP, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. "Ketone body β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature Medicine, 2015 Mar;21(3):263-9 DOI: 10.1038/nm.3804.

26.  Ari, C., Poff, A.M., Held, H.E., Landon, C.S., Goldhagen, C.R., Mavromates, N., D’Agostino, DP. Metabolic therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model. PLoS One. 2014 Jul 25;9(7):e103526. DOI: 10.1371/journal.pone.0103526

27.  Seyfried T, Flores R, Poff AM, D’Agostino DP, Mukherjee P. Metabolic therapy: A new paradigm for managing malignant brain cancer. Cancer Letters. 2014;356(2): 289-300. DOI: 10.1016/j.canlet.2014.07.015.

28.  Rauch J, Silva JE, Lowery RP, McCleary SA, Shields KA, Ormes JA, Sharp MH, Weiner SI, Georges JI, Volek JS, D’Agostino DP, Wilson JM (2014): The effects of ketogenic dieting on skeletal muscle and fat mass. JISSN. 11(Suppl1):P40. doi.org/10.1186/1550-2783-11-S1-P40

29.  Seyfried TN, Marsh J, Mukherjee P, Zuccoli G, D’Agostino DP. Could Metabolic Therapy Become a Viable Alternative to the Standard of Care for Managing Glioblastoma? Oncology & Hematology Review, 2014;10(1):13–20. DOI: 10.17925/USN.2014.10.01.48

30.  Seyfried TN, Poff A, D’Agostino DP. Cancer as a Metabolic Disease: Implications for Novel Therapeutics. Carcinogenesis. 2014, Mar;35(3):515-27. DOI: a10.1093/carcin/bgt480.

31.  Poff A, Ari C, Seyfried TN, D’Agostino DP. Ketone Supplementation Decreases Tumor Cell Viability and Prolongs Survival of Mice with Metastatic Cancer. International Journal of Cancer: 2014 Oct. 1;135(7):1711-20. DOI: 10.1002/ijc.28809

32.  Brownlow ML, Benner L, Benner L, Joly-Amando A, Azam S, D’Agostino DP, Gordon MN, Morgan D. Calorie restriction, but not ketogenic diet, improves cognition in models of Alzheimer's pathology. Alzheimers’s and Dementia. 2013 9(4): P160. DOI: 10.1016/j.jalz.2013.05.240

33.  Brownlow ML, Benner L, D’Agostino DP, Gordon MN, Morgan D. Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology. PLoS One. 2013 Sep 12;8(9):e75713. DOI: 10.1371/journal.pone.0075713.

34.  Poff A, Ari C, Seyfried TN, D’Agostino, DP. The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer.  PLoS One., 2013; 8 (6): e65522 DOI: 10.1371/journal.pone.0065522

35.  D’Agostino, D.P., Pilla, R., Held, H.E., Landon, C.S., Puchowicz, M., Brunengraber, H., Ari, C., Arnold, P. and Dean, J.B. Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats.  AJP Regulatory, Integrative and Comparative Physiology, 2013 May 15;304(10):R829-36. DOI: 10.1152/ajpregu.00506.2012.

36.  Paoli A, Grimaldi K, D'Agostino D, Cenci L, Moro T, Bianco A, Palma A. Ketogenic diet does not affect strength performance in elite artistic gymnasts. Journal of International Society Sports Nutrition. 2012 July 26;9(1):34, DOI: 10.1186/1550-2783-9-34

37.  D'Agostino DP, McNally H, Dean JB. Hyperbaric atomic force microscopy (AFM) and fluorescence microscopy for biological applications. Journal of Microscopy; Jan 12; 245 (3), 2012. DOI: 10.1111/j.1365-2818.2011.03599.x. PMID: 22455392

38.  D'Agostino DP, McNally H, Dean JB. Development and testing of hyperbaric atomic force microscopy (AFM) for biological applications. Microscopy and Microanalysis, 2011. vol. 16, issue S2, pp. 1042-1043. DOI: 10.1017/S1431927610057739.

39.  D'Agostino DP, Olson JE, Dean JB. Acute hyperoxia increases lipid peroxidation and induces plasma membrane blebbing in human U87 glioblastoma cells. Neuroscience; 2009; Mar 31;159(3):1011-22. DOI: 10.1016/j.neuroscience.2009.01.062. PMID: 19356685

40.  D’Agostino DP, Mazza EM, Neubauer JA. (2008) Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons.  AJP Regulatory, Integrative and Comparative Physiology. 2009. Jan;296(1):R102-18. 10.1152/ajpregu.90325 PMID: 18971354

41.  D'Agostino DP, Colomb DG Jr, Dean JB. Effects of hyperbaric gases on membrane nanostructure and function in neurons. J Appl Physiol. 2009 Mar;106(3):996-1003 Review. PMID: 18818382. DOI: 10.1152/japplphysiol.91070.2008.

42.  D’Agostino DP, Putnam RW, and Dean JB. Superoxide (·O2-) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen. Journal of Neurophysiology. 2007. Aug;98(2):1030-41. PMID: 17553943